Sputum Interleukin-32 in childhood asthma: correlation with IL-1β

_Background:_ Asthma is an airway disorder where inflammatory cytokines are partly responsible for exacerbating the disease. Interleukin (IL)-32, generally referred to as natural killer cell (NK4) transcript 4, described immunoregulator involved in stimulation of anti-/pro-inflammatory cytokines. The abnormal presence IL-32 has been observed during diseases, particularly asthma. This study aims characterize process patients with severe _Methods:_ and IL-1β levels supernatant induced sputum obtained from 59 asthma (mild: 20 patients; moderate: severe: 19 patients) were measured using ELISA. Sputum mRNA expression was by RT- PCR. _Results:_ significantly elevated at protein (_p= 0.00019_) (_p < 0.0001_) asthmatics compared non-asthmatic controls. asthmatic mild-moderate Severe allergic house dust mites expressed higher level than without allergy = 0.0001_). A significant association found between (r =0.531_; p 0.0159_) In same way, correlated 0.476; _p 0.0337_). _Conclusion:_ may be associated severity.